Cheapest Owner Operators Truck Insurance Cost Winston-Salem, North Carolina

Winston-Salem is a city in and the county seat of Forsyth County, North Carolina, United States. In the 2020 census, the population was 249,545, making it the second-largest municipality in the Piedmont Triad region, the fifth-most populous city in North Carolina, the third-largest urban area in North Carolina, and the 90th-most-populous city in the United States. With a metropolitan population of 675,966, it is the fourth-largest metropolitan area in North Carolina. Winston-Salem is home to the tallest office building in the region, 100 North Main Street, formerly known as the Wachovia Building and now known locally as the Wells Fargo Center.

In 2003, the Greensboro–Winston-Salem–High Point Metropolitan Statistical Area was redefined by the OMB and separated into the two major metropolitan areas of Winston-Salem and Greensboro-High Point. The population of the Winston-Salem metropolitan area in 2020 was 679,948. The metro area covers over 2,000 square miles and spans the five counties of Forsyth, Davidson, Stokes, Davie, and Yadkin.

Winston-Salem is called the “Twin City” for its dual heritage, and “the Camel City” is a reference to the city’s historic involvement in the tobacco industry related to locally based R. J. Reynolds’ Camel cigarettes. Many natives of the city and North Carolina refer to the city as “Winston” in informal speech. Winston-Salem is also home to six colleges and institutions, most notably Wake Forest University, Winston-Salem State University, and the University of North Carolina School of the Arts, which ranks as one of the best arts schools in America. In 2021, the city ranked 46th out of 150 cities on the “Best Places to Live” list from U.S. News & World Report. In April 2021, a study from Lendingtree’s Magnify Money blog ranked Winston-Salem the second-best tech market for women.

Siouan-speaking tribes such as the Cheraw and the Keyauwee Indians inhabited the area. Followers of the Moravian Church had interacted with Cherokees. The city of Winston-Salem is a product of the merging of the two neighboring towns of Winston and Salem in 1913.

The origin of the town of Salem dates to 1753, when Bishop August Gottlieb Spangenberg, on behalf of the Moravian Church, selected a settlement site in the three forks of Muddy Creek. He called this area “die Wachau” (Latin form Wachovia) after the ancestral estate of Count Nicolaus Ludwig von Zinzendorf.
The land, just short of 99,000 acres (400 km), was subsequently purchased from John Carteret, 2nd Earl Granville.

On November 17, 1753, the first settlers arrived at what would later become the town of Bethabara. This town, despite its rapid growth, was not designed to be the primary settlement on the tract. Some residents expanded to a nearby settlement, called Bethania, in 1759. Finally, lots were drawn to select among suitable sites for the location of a new town.

The town established on the chosen site was given the name of Salem (from “Shalom”, Hebrew meaning “Peace”, after the Canaanite city mentioned in the Book of Genesis) chosen for it by the Moravians’ late patron Count Zinzendorf. On January 6, 1766, the first tree was felled for the building of Salem. Salem was a typical Moravian settlement congregation, with the public buildings of the congregation grouped around a central square (today Salem Square). These included the church, a Brethren’s House, and a Sisters’ House for the unmarried members of the congregation, which owned all the property in town. For many years, only members of the Moravian Church were permitted to live in the settlement. This practice had ended by the American Civil War. Many of the original buildings in the settlement have been restored or rebuilt and are now part of Old Salem Museums & Gardens.

Salem was incorporated as a town in December 1856. Salem Square and “God’s Acre”, the Moravian graveyard, have been the site of the Moravian sunrise service each Easter morning since 1772. This service, sponsored by all the Moravian church parishes in the city, attracts thousands of worshipers each year, some from overseas.

In 1849, the Salem Congregation sold land north of Salem to the newly formed Forsyth County for a county seat. The new town was called “the county town” or Salem until 1851, when it was renamed Winston for a local hero of the Revolutionary War, Joseph Winston. For its first two decades, Winston was a sleepy community. In 1868, work began by Salem and Winston business leaders to connect the town to the North Carolina Railroad. By the 1880s, there were many different tobacco factories in the town, with notable ones owned by Pleasant Hanes and R.J. Reynolds. Pleasant Hanes would later go on to found Hanes (formerly called Shamrock Knitting Mills) in 1900.

Robert Gray, as a featured speaker at the 1876 centennial celebration, was the first to mention the two towns as one. In the 1880s, the US Post Office began referring to the two towns together as Winston-Salem. In 1899, after nearly a decade of contention, the United States Post Office Department established the Winston-Salem post office in Winston, with the former Salem office serving as a branch. After a referendum the towns were officially incorporated as “Winston-Salem” in 1913.

The Reynolds family, namesake of the R. J. Reynolds Tobacco Company, played a large role in the history and public life of Winston-Salem. By the 1940s, 60% of Winston-Salem workers worked either for Reynolds or in the Hanes textile factories. The Reynolds company imported so much French cigarette paper and Turkish tobacco for Camel cigarettes that Winston-Salem was designated by the United States federal government as an official port of entry for the United States, despite the city being 200 miles (320 km) inland. Winston-Salem was the eighth-largest port of entry in the United States by 1916.

In 1917, the Reynolds company bought 84 acres (340,000 m) of property in Winston-Salem and built 180 houses that it sold at cost to workers, to form a development called “Reynoldstown”. By the time R.J. Reynolds died in 1918, his company owned 121 buildings in Winston-Salem.

In 1920, with a population of 48,395, Winston-Salem was the largest city in North Carolina.

In 1929, the Reynolds Building was completed in Winston-Salem. Designed by William F. Lamb from the architectural firm Shreve, Lamb and Harmon, the Reynolds Building is a 314-foot (96 m) skyscraper that has 21 floors. When completed as the headquarters of R.J. Reynolds Tobacco Company, it was the tallest building in the United States south of Baltimore, Maryland, and it was named the best building of the year by the American Institute of Architects. The building is well known for being the predecessor and prototype for the much larger Empire State Building, which was built in 1931 in New York City.

In 1892, Simon Green Atkins founded Slater Industrial Academy, which later became Winston-Salem State University, a public HBCU. In 1956, Wake Forest College, now known as Wake Forest University, moved to Winston-Salem from its original location in Wake Forest, North Carolina.

The governing body for the City of Winston-Salem is an eight-member City Council (called the Board of Aldermen until December 2002). Voters go to the polls every four years in November to elect the mayor and council. The mayor is elected at large; council members are elected by citizens in each of the eight wards within the city. The City Council is responsible for adopting and providing for all ordinances, rules and regulations as necessary for the general welfare of the city. It approves the city budget and sets property taxes and user fees. The Council appoints the city manager and city attorney, and approves appointments to city boards and commissions.

As of September 2020, the mayor of Winston-Salem was Allen Joines (D), who was first elected in 2001 and is the longest-serving mayor in the history of the city. The members of the City Council were Mayor Pro Tempore Denise “D.D.” Adams (D–North Ward), Barbara Hanes Burke (D–Northeast Ward), Annette Scippio (D–East Ward), James Taylor Jr. (D–Southeast Ward), John Larson (D–South Ward), Kevin Mundy (D–Southwest Ward), Robert Clark (R–West Ward), and Jeff MacIntosh (D–Northwest Ward).

City officials appointed by the City Council include the city attorney – Angela Carmon – and the city manager. Longtime city manager Lee Garrity retired on June 23, 2023, after serving for 17 years. He was replaced by Interim City Manager Johnnie Taylor. On July 14, the City Council voted to hire William Patrick “Pat” Pate of Manassas, Virginia, to fill the position permanently.

The city of Winston-Salem is patrolled by the Winston-Salem Police Department, and the chief of police is William H. Penn. Fire protection is provided by the Winston-Salem Fire Department, and the chief of the department is William “Trey” Mayo.

Winston-Salem is in the northwest Piedmont area of North Carolina, situated 65 miles (105 km) northwest of the geographic center of the state. According to the United States Census Bureau, as of 2016 the city had a total area of 133.7 square miles (346.3 km), of which 132.4 square miles (343.0 km) is land and 1.2 square miles (3.2 km), or 0.93%, is water. The city lies within the Yadkin–Pee Dee River Basin, draining mainly via Salem Creek, Peters Creek, Silas Creek, and Muddy Creek.

Less than 30 miles (48 km) north of Winston-Salem are the remains of the ancient Sauratown Mountains, named for the Saura people who lived in much of the Piedmont area, including what is now Winston-Salem.

Winston-Salem is located 16 miles northwest of High Point, 25 miles west of Greensboro, and 69 miles northeast of Charlotte.

The city of Winston-Salem consists of 66 constituent neighborhoods, covering 25 ZIP codes and a total area of 134.74
square miles. Winston-Salem is the 72nd-largest city by area in the United States and the fifth-largest city in North Carolina by population.

Downtown, the central business district of Winston-Salem, is the largest in the Piedmont Triad region. With a population of approximately 14,000 and a workforce of over 27,000, downtown Winston-Salem is a hotspot for growth. Fourth Street, the “main drag”, consists of bars, restaurants, retail, hotels, and luxury residential units. The area is surrounded by Northwest Boulevard to the north and west, Salem Parkway to the south, and U.S. Route 52 to the east. Downtown features attractions such as Innovation Quarter, Truist Stadium, Old Salem and the Benton Convention Center.

One of the most notable neighborhoods in the city, West End, features the West End Historic District, which covers an area of 229 acres and is predominantly residential. Most of the buildings in West End were built between 1887 and 1930. Major thoroughfares in West End are West End Boulevard, Northwest Boulevard, and West First Street, which leads into downtown Winston-Salem. The neighborhood offers an urban lifestyle, with shops, parks, restaurants, and services all located within the neighborhood.

Ardmore, the largest neighborhood in Winston-Salem, features the Ardmore Historic District, which contains over 2,000 buildings and two sites. Ardmore is near Wake Forest Baptist Medical Center, the second-largest hospital in North Carolina. Wake Forest Baptist Health is the largest employer in Forsyth County, with over 13,000 employees, and serves North Carolina, Virginia, Tennessee, and South Carolina. Major thoroughfares in Ardmore are South Hawthorne Road, Miller Street, Cloverdale Avenue, and Queen Street.

Sitting northwest of downtown, Buena Vista is close to a wide range of activities and services, such as the Reynolda House and Reynolda Gardens. It is known around Winston-Salem for its quiet tree-lined streets, which give it an “exclusive” feel; most homes in Buena Vista cost between $600,000 and several million dollars. The neighborhood is about ten minutes from downtown and five minutes from one of the city’s upscale shopping centers, Thruway. Thruway Center features national chains such as Trader Joe’s, Athleta, and J.Crew.

Located seven miles southwest of downtown is the busiest shopping district in Winston-Salem and Forsyth County. The corridor offers a variety of national “big box” retailers, including Target, Costco, and Ethan Allen. Two major companies, Novant Health and Truliant Federal Credit Union, call the boulevard home. The intersection of Hanes Mall Boulevard and Stratford Road is the second-busiest intersection in Winston-Salem, with an average daily traffic count of 54,000.

North Winston is located three miles northeast of downtown, with Patterson Avenue running north to south and 25th Street serving as the east–west thoroughfare. The area is bound by University Parkway to the west and U.S. Route 52 to the east, stretching from 13th Street to 30th Street.

The university area is situated in the north-central and northwestern sections of the city, and contains some of Winston-Salem’s busiest thoroughfares. University Parkway, the 4- to 8-lane boulevard named after Wake Forest University, serves as the downtown–north connector. Neighborhoods within the area include Alspaugh and Mount Tabor. The area is bound by North Point Boulevard to the north, Coliseum Drive to the south, University Parkway to the east, and Silas Creek Parkway and Reynolda Road to the west. Other thoroughfares within the area are Polo Road, Reynolds Boulevard, and Deacon Boulevard. Attractions in the area include the Winston-Salem Entertainment-Sports Complex, which includes LJVM Coliseum; the Winston-Salem Fairgrounds; Winston-Salem Fairgrounds Annex; Truist Field; Truist Stadium; and David F. Couch Ballpark. The Winston-Salem Fairgrounds also hosts the Carolina Classic Fair, formerly the Dixie Classic Fair. The fair is one of the most visited fairs in North America and the second-most visited in North Carolina, next to the North Carolina State Fair.

Community renovations are planned for the corner of Peters Creek Parkway and Academy Street. On September 11, 2018, The Winston-Salem Journal reported that The City of Winston-Salem Committee had approved the Peters Creek Community Initiative project, which is a collaboration of The Shalom Project, the North Carolina Housing Foundation, and The National Development Council. The group plans to purchase the former Budget Inn property and build 60 apartment units with a 4,000-square-foot community space. PCCI plans to build a four-story building that will house The Shalom Project in the bottom floor, along with other businesses.

The city of Winston-Salem has a humid subtropical climate, characterized by cool winters and hot, humid summers. The Köppen Climate Classification subtype for this climate is Cfa. The average high temperatures range from 51 °F (11 °C) in the winter to around 89 °F (32 °C) in the summer. The average low temperatures range from 28 °F (−2 °C) in the winter to around 67 °F (19 °C) in the summer.

Note: the US Census treats Hispanic/Latino as an ethnic category. This table excludes Latinos from the racial categories and assigns them to a separate category. Hispanics/Latinos can be of any race.

As of the 2020 United States census, there were 249,545 people, 94,884 households, and 53,708 families residing in the city.

Winston-Salem’s population grew by 8.7% from 2010 to 2020, making it the fifth largest city in North Carolina.

As of the estimate of 2017, the population was 244,605, with 94,105 households and a population density of 1,846 people per square mile.

Winston-Salem was 53.0% female, and 27.8% of its firms were owned by women. The median age was 35 years. 23.9% of the population was under 18 years old, and 13.7% of the population was 65 years or older.

The racial composition of the city in 2017 was 56.1% White, 34.7% Black or African American, 2.2% Asian American, 0.3% Native American, 0.1% Native Hawaiian and other Pacific native alone, and 2.3% two or more races. In addition, 14.8% was Hispanic or Latino, of any race. Non-Hispanic Whites were 45.8% of the population in 2017.

38.4% were married couples living together, 17.3% had a female householder with no husband present, and 39.7% were non-families. 33.1% of all households were made up of individuals, and 10.3% had someone living alone who was 65 years of age or older. The average household size was 2.38 and the average family size was 3.06.

The median household income was $41,228, and the median family income was $53,222. The mean household income was $60,637, and the mean family income was $74,938. Males had a median income of $41,064, versus $33,683 for females. The per capita income for the city was $24,728. 20.6% of the population and 15.7% of all families were below the poverty line. 26.2% of the total population, 31.6% of those under the age of 18, and 8.2% of those 65 and older were living below the poverty line.

About 54.14% of the population identifies as being religiously affiliated. Christianity is the largest religion, with Baptists (15.77%) making up the largest religious denomination, followed by Methodists (12.79%) and Catholics (4.39%). Pentecostals (2.97%), Episcopalians (1.3%), Presbyterians (2.59%), Lutherans (0.96%), Latter-Day Saints (0.90%) make up a significant amount of the Christian population as well. The remaining Christian population (11.93%) is affiliated with other churches such as the Moravians and the United Church of Christ. Islam (0.43%) is the second-largest religion, after Christianity, followed by Judaism (0.20%). Eastern religions (0.02%) make up the religious minority.

The city’s long history with the Moravian church has had a lasting cultural effect. The Moravian star is used as the city’s official Christmas street decoration. In addition, a 31-foot Moravian star, one of the largest in the world, sits atop the North Tower of Wake Forest Baptist Medical Center during the Advent and Christmas seasons. Another star sits under Wake Forest University’s Wait Chapel during the Advent and Christmas seasons as well. Moravian star images also decorate the lobby of the city’s landmark Reynolds Building.

Winston-Salem is the location of the corporate headquarters of HanesBrands, Inc., Krispy Kreme Doughnuts, Inc., Lowes Foods Stores, Quality Oil Company, ISP Sports, Reynolds American (parent of R. J. Reynolds Tobacco Company), Reynolda Manufacturing Solutions, K&W Cafeterias (until 2022), and TW Garner Food Company (makers of Texas Pete). Blue Rhino, the nation’s largest propane exchange company and a division of Ferrellgas, is also headquartered in Winston-Salem. Wachovia Corporation was based in Winston-Salem until it merged with First Union Corporation in September 2001; the corporate headquarters of the combined company was located in Charlotte, until the company was purchased by Wells Fargo in December 2008. PepsiCo has its customer service center located in Winston-Salem. BB&T was also based in Winston-Salem until it was merged with SunTrust Banks in December 2019; the corporate headquarters of the combined company were relocated to Charlotte.

Although traditionally associated with the textile and tobacco industries, Winston-Salem is transforming itself to be a leader in the nanotech, high-tech and biotech fields. Medical research is a fast-growing local industry, and Wake Forest Baptist Medical Center is the largest employer in Winston-Salem. In December 2004, the city entered into a deal with Dell Corporation, providing millions of dollars in incentives to build a computer assembly plant nearby in southeastern Forsyth County. Dell closed its Winston-Salem facility in January 2010 due to the poor economy. In January 2015, Herbalife opened a manufacturing facility in the space left vacant by Dell.

Public and private investment of $713 million has created the Wake Forest Innovation Quarter, an innovation district in downtown Winston-Salem which features business, education in biomedical research and engineering, information technology and digital media, as well as public gathering spaces, apartment living, restaurants, and community events.

According to the Winston-Salem Business Inc.’s 2012–2013 data report on major employers, the ten largest employers in the city were:

According to the Winston-Salem Business Inc.’s 2012 data report on major industries, the major industries in Winston-Salem/Forsyth County are by percentage:

Winston-Salem was officially dubbed the “City of Arts and Innovation” in 2014.

The city created the first arts council in the United States (Arts Council of Winston-Salem Forsyth County), founded in 1949, because of the local art schools and attractions. These include the University of North Carolina School of the Arts, The Little Theatre of W-S, Winston-Salem Theatre Alliance, Spirit Gum Theatre Co., the Piedmont Opera Theater, the Winston-Salem Symphony, the Stevens Center for the Performing Arts, the Downtown Arts District, the Milton Rhodes Center for the Arts, the Hanesbrands Theater, Piedmont Craftsmen, and the Sawtooth School for Visual Arts.

The city’s Arts District is centered around Sixth and Trade Streets, where there are many galleries, restaurants and workshops; nearby is also the ARTivity on the Green art park, established by Art for Art’s Sake.

Winston-Salem is also home to the Southeastern Center for Contemporary Art (SECCA), and the Reynolda House Museum of American Art (the restored 1917 mansion built by the founder of the R. J. Reynolds Tobacco Company and now affiliated with Wake Forest University).

The city plays host to the National Black Theatre Festival, the RiverRun International Film Festival and the Reynolda Film Festival.

Winston-Salem is also the home of the Art-o-mat and houses nine of them throughout the city.

The city is also home to Carolina Music Ways, a grassroots arts organization focusing on the area’s diverse, interconnected music traditions, including bluegrass, blues, jazz, gospel, old-time stringband, and Moravian music.

Once a year the city is also the home of the Heavy Rebel Weekender music festival, featuring over 70 bands, primarily rockabilly, punk and honky tonk, over three days.

The east end of downtown Winston-Salem is anchored by the Innovation Quarter, one of the fastest-growing urban-based districts in the United States. Governed by the Wake Forest School of Medicine, the Innovation Quarter is home to 90 companies, over 3,600 workers, 1,800 students seeking a college degree, and more than 8,000 workforce trainees. The Innovation Quarter is a place for research, business, biomedical science, digital media, and clinical services. It consists of over 1,900,000 square feet (180,000 m) feet of office, laboratory, and educational space covering more than 330 acres (130 hectares). There are more than 1,000 residential units within the Innovation Quarter. The goal is to drive even more economic development and create programs for tenants and residents for new ideas. Because of its location in downtown Winston-Salem, the Innovation Quarter serves as a creative and welcoming urban place for scientists, innovators, and technology leaders. In 2019, the Innovation Quarter became one of the first nine steering committee members of the Global Institute on Innovation Districts, making it one of the leading districts of its kind in the world.

Winston-Salem is home to Hanes Mall, one of the largest shopping malls in North Carolina. The area surrounding the mall along Stratford Road and Hanes Mall Boulevard has become one of the city’s largest shopping districts.

Other notable shopping areas exist in the city, including The Thruway Center (the city’s first shopping center), Hanes Point Shopping Center, Hanes Commons, Stratford Commons, Stratford Village, Reynolda Village, Pavilions, Shoppes at Hanestowne Village, Burke Mill Village Shopping Center, Oak Summit Shopping Center, Stone’s Throw Plaza, Cloverdale Plaza Shopping Center Silas Creek Crossing, and the Marketplace Mall.

The Winston-Salem State University Rams have men’s and women’s NCAA Division II sports teams, which are members of the Central Intercollegiate Athletic Association (CIAA).

The Winston-Salem Dash are a Class High-A Minor-League baseball team currently affiliated with the Chicago White Sox. After 52 years at historic Ernie Shore Field, the Dash now play their home games at the new Truist Stadium, which opened in 2010. Previous names for the team include the Winston-Salem Cardinals, Twins, Red Sox, Spirits and, most recently, the Winston-Salem Warthogs. Players have included Vinegar Bend Mizell, Earl Weaver, Bobby Tiefenauer, Harvey Haddix, Stu Miller, Ray Jablonski, Don Blasingame, Gene Oliver, Rico Petrocelli, Jim Lonborg, George Scott, Sparky Lyle, Bill “Spaceman” Lee, Dwight Evans, Cecil Cooper, Butch Hobson, Wade Boggs, Carlos Lee, Joe Crede, Jon Garland, and Aaron Rowand, all of whom have played extensively at the major league level.

The Carolina Thunderbirds minor-league hockey team began play in 2017 at the Winston-Salem Fairgrounds Annex in Winston-Salem.

Wake Forest University is an original member of the Atlantic Coast Conference (ACC). Wake Forest’s football team plays its games at Truist Field at Wake Forest (formerly BB&T Field, and Groves Stadium), which seats 32,500. Wake Forest’s soccer program made four consecutive final four appearances (2006–2009) and were NCAA champions in 2007.

The Lawrence Joel Veterans Memorial Coliseum is home to Wake Forest and some Winston-Salem State basketball games.

NASCAR Whelen All-American Series racing takes place from March until August at Bowman Gray Stadium. The K&N Pro Series East also races here. It is NASCAR’s longest-running racing series, dating to the 1940s. In the fall, the stadium is used for Winston-Salem State Rams football games.

Winston-Salem hosts an ATP tennis tournament every year, the Winston-Salem Open. The matches are played at the Wake Forest tennis center.

Winston-Salem/Forsyth County Schools has most of its schools inside Winston-Salem. WS/FC Schools include 51 elementary schools, 25 middle schools and 13 high schools. The school with the largest student body population is West Forsyth High School, with over 2,400 students as of the 2017–2018 school year. The district is the most diverse school system in North Carolina. Winston-Salem/Forsyth County School System is the fourth-largest school system in North Carolina, with about 59,000 students and over 90 schools operating in the district.

Private and parochial schools also make up a significant portion of Winston-Salem’s educational establishment.

Winston-Salem has a number of colleges and universities, including:

The Winston-Salem Journal is the main daily newspaper in Winston-Salem. Yes! Weekly is a free paper covering news, opinion, arts, entertainment, music, movies and food. Triad City Beat is a free weekly paper in the Triad area that covers Winston-Salem. The Winston-Salem Chronicle is a weekly newspaper that focuses on the African American community.

These radio stations are located in Winston-Salem, and are listed by call letters, station number, and name. Many more radio stations can be picked up in Winston-Salem that are not located in town.

Winston-Salem makes up part of the Greensboro/Winston-Salem/High Point television designated market area. These stations are listed by call letters, channel number, network and city of license.

The Winston-Salem Transit Authority (WSTA) has the responsibility of providing public transportation. It took over from the Safe Bus Company, founded in the 1920s as the largest black-owned transportation company in the United States, in 1972. Operating out of the Clark Campbell Transportation Center at 100 West Fifth Street, WSTA operates 30 daytime bus routes, 24 of which also provide night service; 24 routes that operate from morning until midnight on Saturday; and 16 Sunday routes. WSTA makes nearly 3 million passenger-trips annually. In February 2010 WSTA added 10 diesel–electric buses to its fleet.

The Piedmont Authority for Regional Transportation (PART) operates a daily schedule from the Campbell Center connecting Winston-Salem to Boone, Mt. Airy, High Point and Greensboro, where other systems provide in-state routes to points east. PART also offers Route 5 (the Amtrak Connector), which provides daily service to and from the Amtrak station in High Point multiple times during the day.

US 52 (which runs concurrent with NC 8) is the predominant north–south freeway through Winston-Salem; it passes near the heart of downtown. US 421 (Salem Parkway) is the main east–west freeway through downtown Winston-Salem; this was the original routing of I-40, and was the main east–west route through the city until 1992, when a bypass loop of I-40 was completed. US 421 splits in the western part of the city onto its own freeway west (signed north) toward Wilkesboro and Boone, North Carolina. I-74 (which was once US 311) links Winston-Salem to High Point (southeast). Silas Creek Parkway is a partial limited access corridor that traverses from the northwestern section of the city to the south central section. The corridor bypasses several neighborhoods surrounding downtown, and serves as a popular connector to Wake Forest University, Hanes Mall, The LJVM Coliseum, and Forsyth Tech.

The Winston-Salem Northern Beltway is a freeway that will loop around the city to the north, providing a route for I-74 on the eastern section and the Auxiliary Route I-274 on the western section.

In November 2018, US 52 south of I-40 was signed Spur Route I-285.

Major arterial thoroughfares in Winston-Salem include Reynolda Road (which also carries NC 67 for a portion of its length), NC 150 (Peters Creek Parkway), US 158 (Stratford Road), University Parkway, Hanes Mall Boulevard, Martin Luther King Jr. Drive, North Point Boulevard, Country Club Road, Jonestown Road, Patterson Avenue, Fourth Street, Trade Street, Third Street, Liberty Street, and Main Street.

Winston-Salem is served by Piedmont Triad International Airport in Greensboro. The airport also serves much of the surrounding Piedmont Triad area, including High Point; the Authority that manages the airport is governed by board members appointed by all three cities as well as both of their counties, Guilford and Forsyth.

A smaller airport, known as Smith Reynolds Airport, is located within the city limits, just northeast of downtown. It is mainly used for general aviation and charter flights. Every year, Smith Reynolds Airport hosts an air show for the general public. The Smith Reynolds Airport is home to the Winston-Salem Civil Air Patrol Composite Squadron, also known as NC-082. The Civil Air Patrol is a non-profit volunteer organization.

Winston-Salem is one of the larger cities in the South that are not directly served by Amtrak. However, an Amtrak Thruway Motorcoach operates three times daily in each direction between Winston-Salem and the Amtrak station in nearby High Point, 16 miles east. Buses depart from the Winston-Salem Transportation Center, then stop on the Winston-Salem State University campus before traveling to High Point. From the High Point station, riders can board the Crescent, Carolinian or Piedmont line. These lines run directly to local North Carolina destinations as well as cities across the Southeast, as far west as New Orleans and as far north as New York City.

Winston-Salem’s sister cities are: